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JoVE Journal
Immunology and Infection

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Rescue of Recombinant Zika Virus from a Bacterial Artificial Chromosome cDNA Clone
 

Rescue of Recombinant Zika Virus from a Bacterial Artificial Chromosome cDNA Clone

Article doi: 10.3791/59537
June 24th, 2019

Summary June 24th, 2019

The recent epidemic of Zika virus highlights the importance of establishing reverse genetic approaches to develop vaccines and/or therapeutic strategies. Here, we describe the protocol to rescue an infectious recombinant Zika virus from a full-length cDNA clone assembled in a bacterial artificial chromosome under the control of the human cytomegalovirus immediate-early promoter.

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