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A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands
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A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

Article DOI: 10.3791/59631-v • 08:04 min • January 24th, 2020
January 24th, 2020 •
1, 2,3, 2
1Department of Ophthalmology, Stony Brook University, 2Department of Preventive Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc.

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Summary
Automatic Translation

This article describes the development of a method to induce acute or chronic dry eye disease in rabbits by injecting concanavalin A to all portions of the orbital lacrimal gland system. This method, superior to those already reported, generates a reproducible, stable model of dry eye suitable for the study of pharmacological agents.

Tags

Rabbit Model Aqueous-deficient Dry Eye Disease Concanavalin A Injection Lacrimal Glands Drug Efficacy Studies Ultrasound Guidance Complete Approach Nonsurgical Means Disease Pathophysiology Posterior Incisure Ultrasound Localization Fur Removal Lidocaine Injection Nictating Membrane
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