Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Ramkumar Mathur; Mahabub  Maraj Alam; Xiao-Feng Zhao; Yunfei Huang; Xinjun Zhu

doi:10.3791/60067

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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

JoVE Journal
Immunology and Infection

This content is Free Access.

JoVE Journal Immunology and Infection

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

6,912 Views

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10:21 min

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September 12, 2019

DOI:

10.3791/60067-v

DOI:

10.3791/60067-v

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10:21 min

September 12, 2019

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2 Views

Ramkumar Mathur^1,2,3, Mahabub Maraj Alam⁴, Xiao-Feng Zhao⁴, Yunfei Huang⁴, Xinjun Zhu^1,2

¹Department of Molecular and Cellular Physiology,Albany Medical College, ²The IBD Center, Division of Gastroenterology, Department of Medicine,Albany Medical College, ³Department of Geriatrics, School of Medicine and Health Science,University of North Dakota, ⁴Department of Neuroscience and Experimental Therapeutics,Albany Medical College

Summary

In this study, we describe a detailed procedure of TNBS-mediated intestinal fibrosis, which exhibits comparable pathophysiology to Crohn's fibrosis. We also discuss this approach in light of rapamycin facilitated inhibitory effects on intestinal fibrosis.