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JoVE Journal
Medicine

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Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
 

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Article DOI: 10.3791/60126-v
January 8th, 2020

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Summary January 8th, 2020

A novel approach is presented to induce chronic dry eye disease in rabbits by surgically removing all orbital lacrimal glands. This method, distinct from those previously reported, produces a stable, reproducible model of aqueous deficient dry eye well suited to study tear physiology and pathophysiology and ocular therapeutics.

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