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JoVE Journal Neuroscience
Entrega intrathecal de oligonucleotides do antisense no sistema nervoso central do rato
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Entrega intrathecal de oligonucleotides do antisense no sistema nervoso central do rato

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

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Aqui, descrevemos um método para entregar drogas ao sistema nervoso central do rato implantando um cateter no espaço intrathecal lombar da espinha. Nós nos concentramos na entrega de oligonucleotídeos antisenso, embora este método seja adequado para a entrega de outras modalidades terapêuticas também.

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Neurociência Edição 152 oligonucleotídeos antisenso barreira hematomental sistema nervoso central parto intrathecal rato RNA medula espinhal
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