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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
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1Department of Molecular and Medical Pharmacology,David Geffen School of Medicine, University of California, Los Angeles, 2Department of Molecular, Cell, and Developmental Biology,University of California, Los Angeles, 3Department of Bioengineering,Hanyang University, 4Department of Ecology and Evolutionary Biology,University of California, Los Angeles, 5Department of Microbiology, Immunology, and Molecular Genetics,University of California, Los Angeles, 6School of Life Sciences,Beijing Normal University, 7Department of Urology, West China Hospital,Sichuan University, 8Department of Urology,David Geffen School of Medicine, University of California, Los Angeles
Chapters
- 00:00Introduction
- 02:03Orthotopic Implantation
- 04:01Results
- 05:03Conclusion
Metastatic clear cell renal cell carcinoma is a disease without a comprehensive animal model for thorough preclinical investigation. This protocol illustrates two novel animal models for the disease: the orthotopically implanted mouse model and the chicken chorioallantoic membrane model, both of which demonstrate lung metastasis resembling clinical cases.
