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1Medical Physics Unit,Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 2Oncology Pharmacy,Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 3Nuclear Medicine Unit,Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 4Radiation Research Unit,Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy, 5Medical Physics Unit,Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy
Chapters
- 00:04Introduction
- 01:24Pre-Infusion Imaging: Transmission and Blank Image Acquisition
- 02:35Post-Infusion Image Acquisition: Planar Image
- 03:21Post-Infusion Image Acquisition: 3D SPECT/CT
- 03:51Image Analysis
- 04:58Blood Sample Measurements and Dosimetry Evaluation
- 05:50Hybrid 2D+3D SCPET/CT Image Analysis
- 06:21Adult Phantom Creation and Red Marrow Evaluation
- 07:50Results: Representative Comparison of 2D, Hybrid 2D+3D, and 3D SPECT/CT Methods for Transient Intestine Uptake Overlap on Kidneys
- 08:35Conclusion
This method estimates the absorbed dose of different structures for peptide-receptor-radionuclide-therapy (PRRT) with the possibility of avoiding organ overlap on 2D-projections. Serial whole-body planar images permit estimation of mean absorbed doses along the whole body, while the hybrid approach, combining planar images and 3D-SPECT/CT image, overcomes the limitations of structure overlapping.
