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JoVE Journal
Cancer Research

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
 

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Article doi: 10.3791/60644
March 17th, 2020

Summary March 17th, 2020

An in vitro model system was developed to capture tissue architectural changes during lung squamous carcinoma (LUSC) progression in a 3-dimensional (3D) co-culture with cancer-associated fibroblasts (CAFs). This organoid system provides a unique platform to investigate the roles of diverse tumor cell-intrinsic and extrinsic changes that modulate the tumor phenotype.

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