Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
JoVE Journal
Medicine
Author Produced

A subscription to JoVE is required to view this content.

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
 

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Article DOI: 10.3791/60695-v 06:12 min April 28th, 2020
April 28th, 2020

Chapters

Summary

This protocol describes a common and feasible method of inducing acute liver injury (ALI) via CCl4 exposure through an orogastric tube. CCl4 exposure induces ALI through the formation of reactive oxygen species during its biotransformation in the liver. This method is used to analyze the pathophysiology of ALI and examine different hepatoprotective strategies.

Transcript

Tags

Acute Liver Injury Rats Carbon Tetrachloride Exposure Orogastric Tube Sprague-Dawley Rats Animal Care Treatment Protocol Room Temperature Tail Vein Cannulation Blood Samples Serum GOT GPT Total Bilirubin Liver Enzymes Biochemical Analysis Carbon Tetrachloride Solution Pathotoxicity Induction Oral Cavity
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter