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Gevalideerd LC-MS/MS Panel voor het kwantificeren van 11 resistente tb-medicijnen in small hair samples
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Gevalideerd LC-MS/MS Panel voor het kwantificeren van 11 resistente tb-medicijnen in small hair samples

Article DOI: 10.3791/60861-v • 08:54 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 2, 3, 4, 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California San Francisco, 2Department of Epidemiology and Biostatistics, University of California San Francisco, 3Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco

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De huidige methoden voor het analyseren van de therapietrouw van patiënten aan complexe resistente tuberculose (DR-TB) regimes kunnen onjuist en resource-intensief zijn. Onze methode analyseert haar, een gemakkelijk verzamelde en opgeslagen matrix, voor concentraties van 11 DR-TB medicijnen. Met behulp van LC-MS / MS, kunnen we bepalen sub-nanogram drug niveaus die kunnen worden gebruikt om beter te begrijpen drug therapietrouw.

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Geneeskunde LC-MS/MS MDR-TB drugs Hair analysis Therapietrouw monitoring Therapeutische drug monitoring Resistente T
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