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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
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JoVE Journal Medicine
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

DOI:
10.3791/60882-v

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07:15 min

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July 28, 2020

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, , , ,
1School of Biomedical Sciences,University of Western Australia, 2Telethon Kids Institute,University of Western Australia, 3College of Science, Health, Engineering and Education,Murdoch University

Chapters

  • 00:04Introduction
  • 00:56Set-up for Partial Surgical Resection of the Tumor
  • 02:23Partial Surgical Resection of the Tumor
  • 04:20Recovery of Mice and Adjuvant or Neoadjuvant Treatment
  • 05:35Results: Tumor Regrowth Following Incomplete Tumor Resection and Immunotherapy
  • 06:35Conclusion

Summary

Automatic Translation

Automatic Translation

In this protocol, we describe a mouse model of incomplete surgical resection of soft tissue sarcoma for testing (neo)adjuvant therapies.

Tags

Keyword Extract: Mouse Model(neo)adjuvant TherapiesResidual DiseaseTumor Debulking SurgeryWound HealingPreclinical StudiesCancer RelapseSubcutaneous InoculationTumor ResectionAnesthesiaSurgical ProcedureTumor ExposureWound Inversion

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