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Højfrekvent ultralyd ekkokardiografi til vurdering zebrafisk hjertefunktion

Article DOI: 10.3791/60976-v • 08:34 min • March 12th, 2020
March 12th, 2020 •
1, 1, 2, 1, 2, 1, 1, 1
1Stanford Cardiovascular Institute, Stanford University, 2Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School

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Vi beskriver en protokol til vurdering af hjertemorfologi og funktion hos voksne zebrafisk ved hjælp af højfrekvent ekkokardiografi. Metoden gør det muligt at visualiseringe hjertet og efterfølgende kvantificering af funktionelle parametre, såsom puls (HR), hjerteoutput (CO), fraktioneret områdeændring (FAC), udslyngningsfraktion (EF) og blodindstrømnings- og udstrømningshastigheder.

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Udviklingsbiologi Udgave 157 Zebrafisk Ekkokardiografi Hjertefunktion Højfrekvent ultralyd Hjerteoutput Udslyngningsfraktion Doppler blodgennemstrømningshastighed
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