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JoVE Journal
Medicine

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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
 

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Article DOI: 10.3791/61029-v 07:42 min May 19th, 2020
May 19th, 2020

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Summary

A rodent model of left heart volume overload from mitral regurgitation is reported. Mitral regurgitation of controlled severity is induced by advancing a needle of defined dimensions into the anterior leaflet of the mitral valve, in a beating heart, with ultrasound guidance. 

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Tags

Mitral Regurgitation Heart Failure Rat Model Valve Disease Volume Overload Controlled Volume Overload Image-guided Technique Echocardiographic Imaging Needle Placement Thoracotomy Suture Microneedle Holder Left Ventricle Transesophageal Echo Probe Ultrasound Guidance
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