An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Daniella Corporan; Takanori Kono; Daisuke Onohara; Muralidhar Padala

doi:10.3791/61029

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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

JoVE Journal
Medicine

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JoVE Journal Medicine

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

6,986 Views

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07:42 min

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May 19, 2020

DOI:

10.3791/61029-v

DOI:

10.3791/61029-v

•

07:42 min

May 19, 2020

•

6959 Views

Daniella Corporan¹, Takanori Kono¹, Daisuke Onohara¹, Muralidhar Padala^1,2

¹Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center,Emory University Hospital Midtown ²Division of Cardiothoracic Surgery, Joseph P. Whitehead Department of Surgery,Emory University School of Medicine

Summary

A rodent model of left heart volume overload from mitral regurgitation is reported. Mitral regurgitation of controlled severity is induced by advancing a needle of defined dimensions into the anterior leaflet of the mitral valve, in a beating heart, with ultrasound guidance.