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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

DOI:
10.3791/61029-v

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07:42 min

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May 19, 2020

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, , ,
1Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center,Emory University Hospital Midtown, 2Division of Cardiothoracic Surgery, Joseph P. Whitehead Department of Surgery,Emory University School of Medicine

Chapters

  • 00:05Introduction
  • 00:54Echocardiography-Guided Mitral Regurgitation (MR)
  • 02:40Animal Recovery and Post-Operative Care
  • 04:45MR Severity Validation
  • 06:01Results: Representative Cardiac Chamber Remodeling and MR Severity
  • 07:03Conclusion

Summary

Automatic Translation

Automatic Translation

A rodent model of left heart volume overload from mitral regurgitation is reported. Mitral regurgitation of controlled severity is induced by advancing a needle of defined dimensions into the anterior leaflet of the mitral valve, in a beating heart, with ultrasound guidance. 

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