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En modificeret to nyre en klip musemodel af reninregulering i nyrearteriestenose
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En modificeret to nyre en klip musemodel af reninregulering i nyrearteriestenose

Article DOI: 10.3791/61058-v • 08:21 min • October 26th, 2020
October 26th, 2020 •
1, 1, 1, 1
1Department of Medicine/Clinical Pharmacology Division, Vanderbilt University Medical Center

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En modificeret 2 nyre 1 klip (2K1C) Goldblatt musemodel blev udviklet ved hjælp af polyurethanrør til at initiere nyrearteriestenose, hvilket inducerede en stigning i reninekspression og nyreskade. Her beskriver vi en detaljeret procedure for forberedelse og placering af manchetten på nyrearterien for at generere en reproducerbar og konsistent 2K1C musemodel.

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Medicin Udgave 164 To nyre et klip (2K1C) Nyrearteriestenose Renin Angiotensin Aldosteron System renin udtryk Nyreskade musemodel
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