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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

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07:45 min

May 18, 2020

DOI:

07:45 min
May 18, 2020

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Summary

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Patient-derived xenograft (PDX) models and transplantable genetically engineered mouse models faithfully recapitulate human disease and are preferred models for basic and translational breast cancer research. Here, a method is described to orthotopically transplant breast tumor fragments into the mammary fat pad to study tumor biology and evaluate drug response.

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