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Cancer Research

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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
 

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Article DOI: 10.3791/61173-v
May 18th, 2020

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Summary May 18th, 2020

Patient-derived xenograft (PDX) models and transplantable genetically engineered mouse models faithfully recapitulate human disease and are preferred models for basic and translational breast cancer research. Here, a method is described to orthotopically transplant breast tumor fragments into the mammary fat pad to study tumor biology and evaluate drug response.

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