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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
DOI:

06:53 min

September 09, 2020

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Chapters

  • 00:05Introduction
  • 01:18Subcutaneous Tumor Induction
  • 03:33Surgical Subcutaneous Tumor Fragment Implantation and Serial and End Point Assessment
  • 05:35Results: Representative Serial Radiography
  • 06:14Conclusion

Summary

Automatic Translation

Bone metastasis models do not develop metastasis uniformly or with a 100% incidence. Direct intra-osseous tumor cell injection can result in embolization of the lung. We present our technique modeling primary bone tumors and bone metastasis using solid tumor graft implantation into bone, leading to reproducible engraftment and growth.

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