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JoVE Journal
Biochemistry
Author Produced

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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
 

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Article doi: 10.3791/61347
October 10th, 2020

Summary October 10th, 2020

Glutathione S-transferases (GSTs) are detoxification enzymes involved in the metabolism of numerous chemotherapeutic drugs. Overexpression of GSTs is correlated with cancer chemotherapy resistance. One way to counter this phenotype is to use inhibitors. This protocol describes a method using a spectrophotometric assay to screen for potential GST inhibitors.

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