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Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Article DOI: 10.3791/61482-v • 09:28 min • September 16th, 2020
September 16th, 2020 •
1,2, 2, 2, 2, 1, 2, 1,3
1Faculty of Medicine and Health Technology, Tampere University & Tampere University Hospital, 2Experimentica Ltd, 3Eye Centre, Tampere University Hospital

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Summary
Automatic Translation

Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.

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Oxygen-induced Retinopathy Model Ischemic Retinal Diseases Rodents Preclinical Studies Neovascular Retinal Diseases Pathological Angiogenesis Neurovascular Response Therapeutic Candidates Retinopathy Of Prematurity Diabetic Retinopathy Wet Age-related Macular Degeneration Hypoxia Induction Weight Recording Soda Lime With Color Indicator Carbon Dioxide Absorption Chamber Humidity And Temperature Monitoring Oxygen Sensor Calibration
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