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Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
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Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

DOI:
10.3791/61482-v

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09:28 min

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September 16, 2020

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, , , , , ,
1Faculty of Medicine and Health Technology,Tampere University & Tampere University Hospital, 2Experimentica Ltd, 3Eye Centre,Tampere University Hospital

Chapters

  • 00:05Introduction
  • 00:54First Experimental Animals and Mouse OIR Model Induction
  • 01:59Drug Administration (Optional)
  • 03:22Tissue Collection and Preparation of Retinal Flat Mounts
  • 06:57Results: Rat and Mouse Models of OIR
  • 08:39Conclusion

Summary

Automatic Translation

Automatic Translation

Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.

Tags

Keywords: Oxygen-induced RetinopathyIschemic Retinal DiseasesRodent ModelRetinopathy Of PrematurityDiabetic RetinopathyAge-related Macular DegenerationHypoxiaAngiogenesisNeovascular Retinal DiseasePreclinical StudiesIn Vivo ImagingOptical Coherence Tomography

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