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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Article DOI: 10.3791/61503-v • 07:25 min • September 22nd, 2020
September 22nd, 2020 •
1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 3, 3, 3
1Experimental Metabolism and Clinical Research Laboratory, Clinical Research Department, Division of Biomedical Research, Centro Médico Nacional 20 de Noviembre, ISSSTE, 2Vascular Surgery and Angiology Department, Centro Médico Nacional 20 de Noviembre, ISSSTE, 3Regenerative Medicine and Tissue Engineering Laboratory; Coordination of Research, Centro Médico Nacional 20 de Noviembre, ISSSTE

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Summary
Automatic Translation

Lower limb amputation may occur even after angioplasty of obstructed vessels in Critical Limb Ischemia (CLI). Mononuclear Progenitor Cells (MPCs) reflect vascular repair. The present protocol describes the quantification of MPCs from circulation close to angioplasty, and its relationship with endothelial dysfunction and prediction of lower limb amputation.

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Angioplasty Critical Limb Ischemia Amputation Local Circulating Mononuclear Progenitor Cells Prognosis Endothelial Dysfunction Risk Stratification Prevention Enforcement Vascular Events Ischemic Heart Disease Lower Limb Ischemia Eduardo Vera-Gomez Alejandro Hernandez-Patricio Carolina Aranda-Rodriguez Juan Ariel Gutierrez-Buendia Atzin Sua Ruiz-Hernandez Mario Antonio Tellez-Gonzalez Gabrielle Alexandra Dominguez-Perez Experimental Metabolism And Tissue Regeneration Gabrielle Hernandez-De Rubin Oscar Antonio Loman-Zuniga Vascular Surgery Department FMD (flow-mediated Dilation) Brachial Artery
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