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JoVE Journal
Immunology and Infection

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
 

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Article DOI: 10.3791/61609
August 12th, 2020

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Summary August 12th, 2020

Infection of neonatal mice with bioluminescent E. coli O1:K1:H7 results in a septic infection with significant pulmonary inflammation and lung pathology. Here, we describe procedures to model and further study neonatal sepsis using longitudinal intravital imaging in parallel with enumeration of systemic bacterial burdens, inflammatory profiling, and lung histopathology.

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