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Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion
Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion
JoVE Journal
Biology
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JoVE Journal Biology
Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion

Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion

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08:24 min

July 27, 2021

DOI:

08:24 min
July 27, 2021

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Summary

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While replication fork collisions with DNA adducts can induce double strand breaks, less is known about the interaction between replisomes and blocking lesions. We have employed the proximity ligation assay to visualize these encounters and to characterize the consequences for replisome composition.

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