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A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
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A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Article DOI: 10.3791/61960-v • 07:12 min • November 24th, 2020
November 24th, 2020 •
*1, *2, 3, 1, 1, 4, 4, 1,5
1Cardiovascular and Metabolic Sciences, Lerner Research Institute; Women’s Health Institute, Cleveland Clinic, 2Women’s Health Institute, Cleveland Clinic, 3Department of Obstetrics and Gynecology, 983255 Nebraska Medical Center, University of Nebraska Medical Center, 4Anatomic Pathology, Cleveland Clinic, 5Gynecologic Oncology, Women’s Health Institute and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic
* These authors contributed equally

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Summary
Automatic Translation

Many rodent models of endometriosis are limited by technical complexity, reproducibility, and/or need for immunocompromised animals or special reporter mice. We present a simplified system of lesion induction using any experimental mouse with an independently verifiable, objective scoring system and with no requirement for ovariectomy or survival surgery.

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Syngeneic Murine Model Endometriosis Naturally Cycling Mice Mirroring Model Microscopic Quantification Objective Quantification Animal Model Bias Reduction Ovariectomy Survival Surgery Reproducible Model Estrous Cycling Urine Soaked Bedding Male Mouse Cage Female Mouse Cage Endometrial Tissue Transplant Pregnant Mare Serum Gonadotropin Sterile Saline Dissecting Scissors Transverse Incision Connective Tissue Trimming
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