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1Cardiovascular and Metabolic Sciences, Lerner Research Institute; Women’s Health Institute,Cleveland Clinic, 2Women’s Health Institute,Cleveland Clinic, 3Department of Obstetrics and Gynecology, 983255 Nebraska Medical Center,University of Nebraska Medical Center, 4Anatomic Pathology,Cleveland Clinic, 5Gynecologic Oncology, Women’s Health Institute and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine,Cleveland Clinic
Chapters
- 00:04Introduction
- 00:53Donor and Recipient Mouse Preparation and Donor Mouse Endometrial Tissue Harvest
- 02:59Peritoneal Tissue Fragment Injection
- 04:03Endometriotic Lesion Harvest
- 04:51Endometriotic Lesion Scoring
- 05:58Results: Representative Endometriosis Lesion Histopathological Analyses
- 06:39Conclusion
Many rodent models of endometriosis are limited by technical complexity, reproducibility, and/or need for immunocompromised animals or special reporter mice. We present a simplified system of lesion induction using any experimental mouse with an independently verifiable, objective scoring system and with no requirement for ovariectomy or survival surgery.
