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JoVE Journal
Bioengineering
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Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
 

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Article doi: 10.3791/61962
January 23rd, 2021

Summary January 23rd, 2021

This protocol aims to fabricate 3D cardiac spheroids (CSs) by co-culturing cells in hanging drops. Collagen-embedded CSs are treated with doxorubicin (DOX, a cardiotoxic agent) at physiological concentrations to model heart failure. In vitro testing using DOX-treated CSs may be used to identify novel therapies for heart failure patients.

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