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Journal / Bioengineering / Cardiale Sferoïden als in vitro Bioengineered…
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Bioengineering
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JoVE Journal Bioengineering
Cardiale Sferoïden als in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
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Cardiale Sferoïden als in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Article DOI: 10.3791/61962-v • 10:41 min • January 23rd, 2021
January 23rd, 2021 •
1,2,3,4, 2,3,4
1University of Newcastle, 2University of Sydney, 3Kolling Institute of Medical Research, Royal North Shore Hospital, 4University of Technology, Sydney

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Dit protocol is bedoeld om 3D-hartsferoïden (CS'en) te fabriceren door cellen in hangende druppels te co-culturing. Collageen-ingebedde ES's worden behandeld met doxorubicine (DOX, een cardiotoxisch middel) bij fysiologische concentraties om hartfalen te modelleren. In vitro testen met dox-behandelde ES's kunnen worden gebruikt om nieuwe therapieën voor patiënten met hartfalen te identificeren.

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Bio-engineering Vascularized cardial sferoïden bio-engineered hartweefsels vascularisatie 3D co-culturen stamcellen cardiomyocyten fibroblasten endotheelcellen in vitro testen doxorubicine cardiotoxiciteit.
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