Name: A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair (Video) | JoVE Journal
Uploaded: 2021-10-16T13:00:00.000+00:00
Duration: 8 min 31 s
Description: Learn a stepwise echocardiographic protocol for transcatheter mitral valve repair using 2D and 3D TEE guidance. This method helps cardiologists optimize procedural safety and outcomes in high-risk patients.

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5 minutes

We thank Ms. Dorothea Scheurlen for technical video support.

The protocol follows the guidelines of our's institution's human research ethics committee.
1. Evaluation before intervention
<ol>
	<li>Exclude pericardial effusion before transseptal puncture. If a small pericardial effusion is present, measure the maximal end-diastolic echolucent space in a four-chamber (4Ch) view with a focus on the right ventricle (RV), a mid-oesophageal right ventricular inflow-outflow view, and a long-axis (LAX) view.</li>
	<li>Evaluate the pulmonary venous flow pattern with pulse wave doppler (PW) in the left upper pulmonary vein (LUPV) and exclude thrombus formation in the left atrial appendage (LAA). Show the short axis (SAX) view with focus on the LAA, sweep then at 40-60° and rotate the probe anti-clockwise to show the LUPV. Assess the flow in the right upper pulmonary vein (RUPV) by sweeping at 90-110° (Figure 1 and Supplementary Figure 1).</li>
</ol>
<img alt="Cardiac ultrasound diagram; echocardiogram Doppler analysis for heart function assessment." class="xfigimg" src="/files/ftp_upload/62053/62053fig01.jpg" data-altupdatedat="1788282455000" data-alt="Figure 1"> 
Figure 1: Modified SAX view: PW flow in the left upper pulmonary vein <a href="https://www.jove.com/files/ftp_upload/62053/62053fig01large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol start="3">
	<li>Ensure hemodynamic state is the same during pre- and post-procedural evaluation. 
	​NOTE: AS MR is a dynamic valve disease, regurgitation may seem less severe under general anaesthesia. In this case, consult the operator and increase the afterload and/or the preload.</li>
	<li>Find the best intercommissural view (50-70°). Take a perpendicular view (X-plane) in the three segments with and without color doppler and measure the length of the posterior mitral leaflet (PML). Then, check the leaflet morphology again (Figure 2 and Supplementary Figure 2).</li>
</ol>
<img alt="Cardiac ultrasound, Doppler echocardiography, heart valve function, blood flow visualization, medical imaging." class="xfigimg" src="/files/ftp_upload/62053/62053fig02.jpg" data-altupdatedat="1788282455000" data-alt="Figure 2"> 
Figure 2: 2D biplanar view of the MV with color doppler: medial insufficiency jet <a href="https://www.jove.com/files/ftp_upload/62053/62053fig02large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol start="5">
	<li>Assess the transmitral pressure gradient with continuous wave doppler (CW) in the long axis view (120-140°). 
	​NOTE: A mean pressure gradient (MPG) &gt; 5 mmHg is a relative contraindication for PMVR.</li>
	<li>Take a 3D dataset with color doppler or a wide-sector zoom image with color and measure the 3D-vena contracta (3D-VCA) (Figure 3).</li>
</ol>
<img alt="Echocardiography frames with color Doppler flow analysis, cardiac imaging, valve assessment." class="xfigimg" src="/files/ftp_upload/62053/62053fig03.jpg" data-altupdatedat="1788282455000" data-alt="Figure 3"> 
Figure 3: Multiplanar reconstruction of the 3D dataset with color doppler: 3D-Vena contracta <a href="https://www.jove.com/files/ftp_upload/62053/62053fig03large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol start="7">
	<li>Without color, use the 3D volume to measure the mitral valve area (MVA) (Supplementary Figure 3). 
	NOTE: An area &lt; 4 cm2 is a relative contraindication, an area &lt; 3 cm2 an absolute contraindication to perform the procedure. Otherwise assess the MVA in the transgastric basal SAX view.</li>
	<li>Show the 3D en-face surgical atrial view (aortic valve at 12 o'clock) of the mitral valve. 
	NOTE: The segments of the valve are named "lateral" for the segments 1 and "medial" for the segments 3. The sequence of the segments in the en-face surgical view, is inverse to the sequence in the commissural view. Perform a 180° clockwise rotation into the 3D en-face surgical view (aortic valve at 6 o'clock), that will result in an equal sequence of segments in both views (Figure 4 and Figure 5).</li>
</ol>
<img alt="3D echocardiography image; heart ultrasound, beating measurement, cardiovascular analysis." class="xfigimg" src="/files/ftp_upload/62053/62053fig4v2.jpg" data-altupdatedat="1788282455000" data-alt="Figure 4"> 
Figure 4: Wide sector zoom image: 3D en-face surgical atrial view (aortic valve at 12 o'clock) <a href="https://www.jove.com/files/ftp_upload/62053/62053fig04large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<img alt="3D echocardiogram of aortic valve, lateral and medial sections labeled, imaging diagnostics." class="xfigimg" src="/files/ftp_upload/62053/62053fig5v2.jpg" data-altupdatedat="1788282455000" data-alt="Figure 5"> 
Figure 5: Wide sector zoom image: 3D en-face atrial view (aortic valve at 6 o'clock) <a href="https://www.jove.com/files/ftp_upload/62053/62053fig05large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol start="9">
	<li>Finally, take a bicaval view (90-110°) with X-plane, to show the aortic valve (AV), for the transseptal puncture.</li>
</ol>
2. Strategy
<ol>
	<li>Discuss the strategy with the operator before inserting the steerable guide catheter (SGC) and the clip delivery system (CDS) into the left atrium.
	<ol>
		<li>Evaluate a one device strategy if the orifice is &lt; 1 cm wide and position the clip directly above the regurgitation jet if the orifice is circular.</li>
		<li>Evaluate the implantation of ≥ 2 clips in case of large elliptic or multiple jets. Implant the device starting medially of the regurgitant orifice, as the positioning of a second device is often easier when the first has been implanted in this way, rather than after starting laterally (Supplementary Figure 4).</li>
	</ol>
	</li>
</ol>
3. Transseptal puncture
<ol>
	<li>Show a bicaval view combined with a SAX view. Ensure the AV is visible, to avoid aortic injury.</li>
	<li>Make sure the puncture site is slightly superior and posterior (Figure 6).</li>
</ol>
<img alt="Cardiac ultrasound showing echocardiography analysis with heart chamber visualization." class="xfigimg" src="/files/ftp_upload/62053/62053fig06.jpg" data-altupdatedat="1788282455000" data-alt="Figure 6"> 
Figure 6: 2D biplanar view: transseptal puncture <a href="https://www.jove.com/files/ftp_upload/62053/62053fig06large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol style="margin-left: 40px;">
	<li>Choose a puncture height of 4-5 cm in case of degenerative MR (e.g., prolapse) and of &gt; 3.5 in functional MR. Avoid a patent foramen ovale, as the entry is far too anterior.</li>
</ol>
<ol start="3">
	<li>Once the transseptal needle leads to tenting of the interatrial septum, measure the puncture height in the 4Ch view in mid-systole (Supplementary Figure 5). 
	NOTE: In patients with large atria, if the puncture site is too posterior the tenting cannot be visualized in the 4Ch view. In this case, retroflex and insert the probe deeper into the oesophagus.</li>
	<li>After transseptal puncture, always exclude pericardial effusion in the 4Ch view.</li>
	<li>Show a SAX view with a focus on the LAA and pulmonary vein to visualize the entering of the stiff guidewire into the LUPV.</li>
</ol>
4. Introduction of the SGC into the LA
<ol>
	<li>Visualize the tenting and advancement of the SGC with the dilator in a SAX view with continuous 2D-echocardiography and fluoroscopic guidance to avoid injuries to the left atrial wall. 
	NOTE: The tip of the SGC is defined by a radiopaque and echo bright double ring (Supplementary Figure 6).</li>
	<li>Show the operator the SAX view and the bicaval view (90-120°) to position the SGC in the direction of the left ventricle (LV).</li>
</ol>
5. Advancement of the CDS into the LA
<ol>
	<li>Take a 3D-volume including the interatrial septum, the left lateral ridge and the MV and ensure that the left lateral ridge is visible because protrusion of the CDS is common (Figure 7).</li>
</ol>
<img alt="3D echocardiography image, cardiac structure visualization for diagnostic analysis and heart function." class="xfigimg" src="/files/ftp_upload/62053/62053fig07.jpg" data-altupdatedat="1788282455000" data-alt="Figure 7"> 
Figure 7: Wide sector zoom image: SGC in the LA including the interatrial septum, the left lateral ridge and the MV <a href="https://www.jove.com/files/ftp_upload/62053/62053fig07large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol style="margin-left: 40px;">
	<li>Otherwise choose the SAX view and the LAX view (X-plane) to ensure, the CDS does not have contact with the ridge and the LA-wall. 
	NOTE: The operator may ask the imager to show the interatrial septum and pull back the SGC a few millimetres to bypass the ridge. If the double ring in 3D cannot be visualized, switch to 2D and show the SGC in the SAX view.</li>
</ol>
<ol start="2">
	<li>Check that the CDS is positioned perpendicularly to the coaptation line to guarantee a correct trajectory.
	<ol>
		<li>Show the intercommissural view in 2D at ca. 60° to display the medial - lateral plane and the LAX view at 120-140° to identify the anterior - posterior plane of the MV (Supplementary Figure 7).</li>
		<li>Alternatively optimize the medial, lateral, anterior, and posterior positioning of the CDS in the 3D en-face view (Supplementary Figure 8).</li>
	</ol>
	</li>
</ol>
6. Orientation of the device above and below the MV
<ol>
	<li>Take the 3D en-face view to show a perpendicular positioning of the arms to the coaptation line.
	<ol>
		<li>In the event of poor image quality, show an intercommissural view combined with a LAX view (Figure 8 and Figure 9).</li>
	</ol>
	</li>
</ol>
<img alt="Cardiac echocardiogram image; ultrasound, heart structure assessment, Doppler analysis." class="xfigimg" src="/files/ftp_upload/62053/62053fig08.jpg" data-altupdatedat="1788282455000" data-alt="Figure 8"> 
Figure 8: 2D biplanar view of the MV: positioning of the device over the mitral valve <a href="https://www.jove.com/files/ftp_upload/62053/62053fig08large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<img alt="3D echocardiogram showing heart structure, used for cardiac assessment and analysis." class="xfigimg" src="/files/ftp_upload/62053/62053fig09.jpg" data-altupdatedat="1788282455000" data-alt="Figure 9"> 
Figure 9: Wide sector zoom image: positioning of the device over the mitral valve <a href="https://www.jove.com/files/ftp_upload/62053/62053fig09large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
NOTE: The clip arms are visible only in the LAX view.
<ol start="2" style="margin-left: 40px;">
	<li>Adjust the intercommissural view angle for medially and laterally positioned devices to visualise the complete length of both arms. Sweep at ca. 30-45° for medially positioned devices and ca. 70-90° for laterally positioned devices.</li>
</ol>
<ol start="2">
	<li>Choose the intercommissural view combined with a LAX view to visualize the advancing of the CDS into the LV.</li>
	<li>Ensure the CDS is placed just a few millimetres below the MV.</li>
	<li>Verify in the 3D en-face view that the clip arms are still in the planned position, as a rotation of the clip while crossing the valve is frequent. 
	NOTE: If the position of the clip arms has changed, clockwise or anticlockwise rotation will be performed to obtain symmetric grasping. Be careful during this manoeuvre to minimize chordal and subchordal entanglement.</li>
	<li>If gross reorientation of the device is necessary, show the intercommissural view with X-plane to visualize the inversion of the clip that will be retrieved into the LA.</li>
</ol>
7. Grasping of the mitral leaflets and assessment of MR before and after clip deployment
<ol>
	<li>Record the grasping of the leaflets in the intercommissural view combined with the LAX view (X-plane) or in the LAX view only (Supplementary Figure 9).</li>
	<li>Ask the anaesthesiologist to perform a breath-hold manoeuvre to reduce shifting during ventilation and to facilitate the grasping of the leaflets.</li>
	<li>Ensure continuous visualisation of leaflet insertion to avoid rolling of the leaflets or the chordae. 
	NOTE: Grasping a rolled leaflet or a chorda may result in a partial leaflet detachment and/or an aggravation of the MR.</li>
	<li>Carefully evaluate the regurgitation reduction before clip deployment. Ensure both, operator and imager analyse this crucial step.
	<ol>
		<li>Rotate the TEE probe medially and laterally to the clip or use X-plane with color doppler to find eccentric jets close to the clip (Supplementary Figure 10). 
		NOTE: Due to shadowing artifacts caused by the CDS underestimation of the MR may occur. Insert the probe deeper into the esophagus or show the transgastric view to visualize the residual insufficiency jets without shadowing artifacts.</li>
		<li>Evaluate the PW flow in the pulmonary veins. 
		NOTE: if a previous systolic flow reversal changes into a systolic dominant pattern, a relevant reduction has probably occurred.</li>
		<li>Measure the MPG across the mitral valve. 
		​NOTE: A gradient &gt; 5 mmHg is a relative contraindication for clip deployment (Supplementary Figure 11 and Supplementary Figure 12).</li>
		<li>Use the 3D en-face view of the MV or a transgastric SAX view of the MV to show the double orifice (Figure 10).</li>
	</ol>
	</li>
</ol>
<img alt="3D echocardiogram image displaying detailed cardiac structure for medical analysis and diagnostics." class="xfigimg" src="/files/ftp_upload/62053/62053fig10.jpg" data-altupdatedat="1788282455000" data-alt="Figure 10"> 
Figure 10: Wide sector zoom image: double orifice of the MV after device deployment <a href="https://www.jove.com/files/ftp_upload/62053/62053fig10large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol start="5" style="margin-left: 40px;">
	<li>Finally, if the result is satisfactory, check leaflet insertion in 2D.</li>
</ol>
<ol start="5">
	<li>After releasing the clip from the CDS, repeat the last five steps. 
	NOTE: Due to the tension of the system on the MV, the residual insufficiency jets after releasing the device may be aggravated.</li>
	<li>Show when the delivery catheter tip is retrieved from the SGC in the LAX view with X-plane and ensure that the spike avoids contact with the LA (Supplementary Figure 13).</li>
</ol>
8. Final MR assessment
<ol>
	<li>Show the intercommissural view with color doppler in combination with perpendicular X-planes in the residual insufficiency jets if present.</li>
	<li>Calculate the 3D-VCA in a 3D-volume. NOTE: usually the orifices are not in the same plane. In this case measure separated planimetries of each orifice in the appropriate planes (Supplementary Figure 14).</li>
	<li>Evaluate once again the pulmonary vein flow and the mean gradient across the mitral valve. 
	NOTE: continuous LA pressure monitoring may be a useful tool during transcatheter mitral valve repair.</li>
	<li>Finally, show the 3D en-face view of the mitral valve.</li>
</ol>
9. Implantation of additional devices
<ol>
	<li>Ensure MR reduction is sufficient. 
	NOTE: If the result is not satisfactory, evaluate the implantation of additional devices.</li>
	<li>Ensure that the additional device does not contact the implanted device diving into the left ventricle. 
	NOTE: fluoroscopy is essential to show the real distance between the clips.</li>
	<li>Show the 3D en-face view to visualize the commissural line, as it might be deferred after implantation of the first clip.</li>
	<li>Repeat the five steps as explained in point 7.4 to evaluate MR after grasping the leaflets with the additional clip.</li>
</ol>

The authors have nothing to disclose.

Echo-guidance for the PMVR is a safe method. Complications due to echocardiography may occur but rarely lead to significant damage. Nevertheless, esophageal lesions are possible after performing transesophageal echocardiography. This incidence is reduced with a shorter duration of the intervention34. On the contrary, several complications associated with the transcatheter edge-to-edge mitral valve repair are described35,36. Major bleeding ...

Mitral regurgitation (MR) is the second-most frequent indication for valve surgery in Europe1. Untreated, it may lead to severe heart failure and reduced quality of life2,3,4. The percutaneous mitral valve repair (PMVR) is a catheter-based technique, which mimics the Alfieri stitch surgical method to mitral repair by connecting the A2 and P2 scallops5. For patients with high surgical risk, this technique offers a minimally invasive approach for the treatment of severe MR. Data from several registries and trials has shown that the MitraClip procedure, a transcatheter mitral valve repair therapy, is an effective and safe method6,7,8,9. In 2019, a similar device, the PASCAL transcatheter valve repair system, was introduced to the market. It has shown feasibility and acceptable safety in the treatment of patients with severe MR10. The duration and success of the PMVR are dependent on the individual operator&#39;s skill and experience11. In contrast to other percutaneous techniques, like the percutaneous transvalvular replacement (TAVR), which can be done with fluoroscopy only, PMVR requires echocardiographic guidance12,13.
This article describes step by step the echocardiographic approach during PMVR, including measurements, suggestions for intraprocedural quantification of the MR and important views to prevent periprocedural complications.

<table><tbody><tr><td>EPIQ 7 Ultrasound System</td><td>Philips</td><td>US218B0542</td><td>Cardiac Ultrasound Machine</td></tr><tr><td>X8-2t xMATRIX 3D-TEE probe</td><td>Philips</td><td>B34YYK</td><td>TEE-probe</td></tr><tr><td>Sheath 6F 25 cm</td><td>Merit Medical</td><td>B60N25AQ</td><td>Sheath</td></tr><tr><td>Dilator 16 F</td><td>Abbott</td><td>405544</td><td>Dilator</td></tr><tr><td>BRK-1 transseptal needle 71 cm</td><td>St. Jude Medical</td><td>ABVA407201</td><td>Transseptal Needle</td></tr><tr><td>Swartz Lamp 90&amp;deg;</td><td>St. Jude Medical</td><td>407356</td><td>Transseptal Guiding Introducer Sheath</td></tr><tr><td>Amplatz super stiff</td><td>Kook Medical</td><td>46509</td><td>Wire</td></tr><tr><td>Steerable Guide Catheter</td><td>Abbott</td><td>SGC0302</td><td>Steerable Guide Catheter</td></tr><tr><td>MitraClip NTR Delivery System</td><td>Abbott</td><td>CDS0602-NTR</td><td>Clip Delivery System</td></tr><tr><td>MitraClip NTR Bundle</td><td>Abbott</td><td>MSK0602-NTR</td><td>Device</td></tr></tbody></table>

a simplified stepwise approach to echo guidance during percutaneous mitral valve repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Percutaneous transcatheter edge-to-edge reconstruction of the mitral valve is a safe and well-established therapy for severe symptomatic mitral regurgitation in patients with high surgical risk. Echocardiographic guidance in addition to fluoroscopy is the gold standard and should be performed using a standardized technique.
This article lays out our reproducible step by step echocardiographic guide including views, measurements as well as highlighting possible difficulties that may arise during the procedure.
This article provides detailed and chronological echocardiographic views for each step of the procedure, especially preferences between 2D and 3D imaging. If needed, pulse wave, continuous wave and color doppler measurements are described. Furthermore, as there are no official recommendations for the quantification of mitral regurgitation during the percutaneous edge-to-edge-repair procedure, advice is also included for echocardiographic quantification after grasping the mitral leaflets and after device deployment. In addition, the article deals with important echocardiographic views to prevent and deal with possible complications during the procedure.
Echocardiographic guidance during transcatheter mitral valve repair is mandatory. A structured approach improves the collaboration between interventionist and imager and is indispensable for a safe and effective procedure.

Percutaneous edge-to-edge valve repair is an alternative to surgical valve repair or replacement in patients not eligible for surgery with symptomatic severe MR. The first clinical application of the MitraClip was investigated in the Endovascular Valve Edge-to-Edge Repair Study I (EVEREST I)14 trial. Many other trials have proven the effectiveness of the procedure with an improvement of symptoms as well as low rates of hospital mortality and adverse events (ACCESS EU, TRAMI, EVEREST II)<sup class=...

This protocol presents in detail how to perform real-time echocardiographic guidance during transcatheter mitral valve repair. The fundamental views and the necessary measurements are described for each stage of the procedure.

Percutaneous transcatheter edge-to-edge reconstruction of the mitral valve is a safe and well-established therapy for severe symptomatic mitral ...

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Learn a stepwise echocardiographic protocol for transcatheter mitral valve repair using 2D and 3D TEE guidance. This method helps cardiologists optimize procedural safety and outcomes in high-risk patients.

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

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