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Hjerterespons på β-adrenerge stimulering bestemt av trykkvolumsløyfeanalyse
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Hjerterespons på β-adrenerge stimulering bestemt av trykkvolumsløyfeanalyse

Article DOI: 10.3791/62057-v • 08:05 min • May 19th, 2021
May 19th, 2021 •
*1,2, *1,2,3, *1,2,4, 1,2, 1,2
1Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, 2DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, 3Department of Internal Medicine III, University of Heidelberg, 4Department of Anesthesiology, University Hospital RWTH Aachen
* These authors contributed equally

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Her beskriver vi en hjertetrykk-volum sløyfe analyse under økende doser av intravenøst infundert isoproterenol for å bestemme den iboende hjertefunksjonen og β-adrenerge reserve hos mus. Vi bruker en modifisert åpen brysttilnærming for trykkvolumsløyfemålingene, der vi inkluderer ventilasjon med positivt sluttutløpstrykk.

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Medisin utgave 171 β-adrenerge stimulering isoproterenol hjertefunksjon trykkvolumløkker hjerte mus in vivo åpen bryst
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