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A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Article DOI: 10.3791/62080-v • 06:44 min • February 28th, 2021
February 28th, 2021 •
*1, *1, 2, 1,2, 1, 1,2
1Department of Surgery, Medical University of South Carolina, 2Ralph H. Johnson Veterans Affairs Medical Center
* These authors contributed equally

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Summary
Automatic Translation

Chronic pancreatitis (CP) is a disease characterized by inflammation and fibrosis of the pancreas, often associated with intractable abdominal pain. This article focuses on refining the technique to generate a mouse model of CP via bile duct infusion with 2,4,6 -trinitrobenzene sulfonic acid (TNBS).

Tags

Chronic Pancreatitis Mouse Model Bile Duct TNBS Infusion Neuropathic Pain Fibrosis Abdominal Pain Von Frey Monofilaments Force Application Positive Response TNBS Solution Ethanol Control Surgical Procedure Veterinary Ointment Disinfectant
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