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Comparative Analysis of Experimental Methods to Quantify Animal Activity in Caenorhabditis elegans Models of Mitochondrial Disease
 

Comparative Analysis of Experimental Methods to Quantify Animal Activity in Caenorhabditis elegans Models of Mitochondrial Disease

Article DOI: 10.3791/62244-v 05:51 min April 4th, 2021
April 4th, 2021

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Summary

This study presents protocols for two semi-automated locomotor activity analysis approaches in C. elegans complex I disease gas-1(fc21) worms, namely, ZebraLab (a medium-throughput assay) and WormScan (a high-throughput assay) and provide comparative analysis among a wide array of research methods to quantify nematode behavior and integrated neuromuscular function.

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Comparative Analysis Experimental Methods Quantify Animal Activity C. Elegans Models Mitochondrial Disease Semiautomated Assays Locomotor Activity Drug Screening Reproducibility Motility Assays Neuromuscular System Glass Slides Worm Pick Stereomicroscope S.basal Solution Technical Replicates Acclimate Swim Activity
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