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JoVE Journal
Biochemistry

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A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline
 

A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline

Article DOI: 10.3791/62306-v 09:00 min
June 17th, 2021

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Summary June 17th, 2021

The signal-to-noise ratio of data is one of the most important considerations in performing X-ray diffraction measurements from microcrystals. The VMXm beamline provides a low-noise environment and microbeam for such experiments. Here, we describe sample preparation methods for mounting and cooling microcrystals for VMXm and other microfocus macromolecular crystallography beamlines.

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