Here, we present a protocol to generate a three-dimensional simplified and undifferentiated skin model using a micromachined microfluidic platform. A parallel flow approach allows the in situ deposition of a dermal compartment for the seeding of epithelial cells on top, all controlled by syringe pumps.
Risueño, I., Valencia, L., Holgado, M., Jorcano, J. L., Velasco, D. Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform. J. Vis. Exp. (171), e62353, doi:10.3791/62353 (2021).