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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Behavior
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JoVE Journal Behavior
Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

DOI:
10.3791/62464-v

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06:39 min

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June 13, 2021

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, ,
1Molecular Developmental Biology Program,Cincinnati Children’s Hospital Medical Center, 2Division of Human Genetics,Cincinnati Children’s Hospital Medical Center, 3Department of Pediatrics,University of Cincinnati College of Medicine, 4Division of Veterinary Services,Cincinnati Children’s Hospital Medical Center

Chapters

  • 00:04Introduction
  • 01:04Performing the Chronic Psychosocial Stress (CGS) Paradigm
  • 04:19Results: Effects of Chronic Psychosocial Stress on Dams and Pups
  • 05:51Conclusion

Summary

Automatic Translation

Automatic Translation

The chronic psychosocial stress (CGS) paradigm employs clinically relevant stressors during pregnancy in mice to model psychiatric disorders of mothers and infants. Here, we provide a step-by-step procedure of applying the CGS paradigm and downstream assessments to validate this model.

Tags

Keywords: Murine ModelPsychosocial StressPregnancyPsychiatric DisordersMaternal Mental HealthAdverse Infant DevelopmentDevelopmental Origins Of Adult DiseaseChronic Gestational Stress (CGS) ParadigmForeign ObjectsPredator OdorCage TiltFrequent Bedding ChangesBedding Removal

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