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A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
DOI:

07:02 min

July 15, 2021

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Chapters

  • 00:04Introduction
  • 00:52Operative Procedure
  • 05:03Chronic PA Banding (9-10 Weeks)
  • 06:07Results: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
  • 06:37Conclusion

Summary

Automatic Translation

This manuscript describes the surgical technique and experimental approach to develop severe right ventricular pressure overload to model their adaptive and maladaptive phenotypes.

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