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A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
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Bioengineering
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JoVE Journal Bioengineering
A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

DOI:
10.3791/62694-v

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07:02 min

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July 15, 2021

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, , , , , , , , , , ,
1Department of Thoracic Surgery,Vanderbilt University Medical Center, 2Department of Biomedical Engineering,Carnegie Mellon University, 3Department of Pediatrics,Columbia University Medical Center, Columbia University Irving Medical Center, 4Department of Medicine,Columbia University Medical Center, Columbia University Irving Medical Center, 5Department of Anesthesiology,Vanderbilt University Medical Center, 6Department of Biomedical Engineering,Vanderbilt University

Chapters

  • 00:04Introduction
  • 00:52Operative Procedure
  • 05:03Chronic PA Banding (9-10 Weeks)
  • 06:07Results: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
  • 06:37Conclusion

Summary

Automatic Translation

Automatic Translation

This manuscript describes the surgical technique and experimental approach to develop severe right ventricular pressure overload to model their adaptive and maladaptive phenotypes.

Tags

Pulmonary HypertensionRight Ventricular FailureLarge Animal ModelLeft Pulmonary Artery LigationPulmonary Artery BandingRV AdaptationRV-targeted TherapeuticsSurgical ProcedureSheep ModelThoracotomyPulmonary Artery DissectionVascular OccluderRight Ventricular Pressure Line

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