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An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
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An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Article DOI: 10.3791/62747-v • 06:40 min • June 8th, 2021
June 8th, 2021 •
1,2,3, 1,4,5, 1, 1, 1,2,3,6, 1,2
1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, 2Department of Anaesthesia, Division of Cancer Surgery, Peter MacCallum Cancer Centre, 3Department of Critical Care, Melbourne Medical School, University of Melbourne, 4Medical Department, Division of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, 5Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 6Sir Peter MacCallum Department of Oncology, University of Melbourne

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Summary
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This paper describes a method for modeling total intravenous anesthesia (TIVA) during cancer resection surgery in mice. The goal is to replicate key features of anesthesia delivery to patients with cancer. The method allows investigation of how anesthetic technique affects cancer recurrence after resection surgery.

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In Vivo Mouse Model Total Intravenous Anesthesia Cancer Resection Surgery Propofol Anesthesia Mouse Models Of Disease Volatile Anesthesia Propofol Anesthesia Impacts Short-term Cancer Outcomes Long-term Cancer Outcomes Tumor Removal Surgery CL4 Mirai Mammary Cancer Cells Firefly Luciferase Expression Alpha MEM Medium 10% FBS 200 Millimolar Glutamine Logarithmic Growth Phase EDTA Solution Hemocytometer PBS Dilution Injection Site Preparation Hamilton Syringe
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