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JoVE Journal Bioengineering
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
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The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Article DOI: 10.3791/63222-v • 07:30 min • January 13th, 2022
January 13th, 2022 •
1, 1, 1, 1, 1,2, 1,2
1Department of Surgery, Section of Plastic Surgery, The University of Michigan Health System, 2Department of Biomedical Engineering, The University of Michigan, Ann Arbor

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Summary
Automatic Translation

This manuscript provides an innovative method for developing a biologic peripheral nerve interface termed the Muscle Cuff Regenerative Peripheral Nerve Interface (MC-RPNI). This surgical construct can amplify its associated peripheral nerve's motor efferent signals to facilitate accurate detection of motor intent and the potential control of exoskeleton devices.

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Muscle Cuff Regenerative Peripheral Nerve Interface Amplification Intact Peripheral Nerve Signals Microvolts Electrodes Reliable Recording MC-RPNI Motor Intent Detection Biological Nature Long-term Interface Distally Innervated Muscle Targets Powered Exoskeleton Devices Extremity Weakness Answer To Shortcomings Longitudinal Incision Anterior Aspect Donor Hindlimb Scalpel Subcutaneous Tissue Dissection Musculature And Tendons Isolation
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