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A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1
 

A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1

Article DOI: 10.3791/63482-v 12:36 min July 22nd, 2022
July 22nd, 2022

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Summary

Descemet's Stripping Only is an experimental procedure wherein patients with central corneal guttae resulting from Fuchs Endothelial Corneal Dystrophy have Descemet's membrane stripped for peripheral cells to regenerate the endothelial layer. We present novel methodology simulating DSO in dystrophic human corneas ex vivo with accelerated healing stimulated by eFGF1 (NM141).

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Human Corneal Organ Culture Model Descemet's Stripping Only Accelerated Healing Engineered Fibroblast Growth Factor 1 Fuch's Endothelial Corneal Dystrophy FECD Corneal Guttae Endothelial Keratoplasty Rejection Risk Endothelial Cell Loss DSO Transplantation Alternative Stromal Edema Vision Improvement Rescue Transplantation
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