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Immunology and Infection

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JoVE Journal Immunology and Infection
En TNBS-induceret gnavermodel til undersøgelse af den patogene rolle af mekanisk stress i Crohns sygdom
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En TNBS-induceret gnavermodel til undersøgelse af den patogene rolle af mekanisk stress i Crohns sygdom

Article DOI: 10.3791/63499-v • 05:08 min • March 1st, 2022
March 1st, 2022 •
*1, *1, *1, 2, 1
1Department of Internal Medicine, the University of Texas Medical Branch, 2Department of Pathology, the University of Texas Medical Branch
* These authors contributed equally

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Den nuværende protokol beskriver udviklingen af en Crohns-lignende colitis-model hos gnavere. Transmural inflammation fører til stenose på TNBS-instillationsstedet, og mekanisk forstørrelse observeres i segmentet proksimalt til stenose. Disse ændringer gør det muligt at studere mekanisk belastning i colitis.

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Immunologi og infektion udgave 181
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