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Journal / Immunology and Infection / En TNBS-inducerad gnagaremodell för att studera…
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Immunology and Infection

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JoVE Journal Immunology and Infection
En TNBS-inducerad gnagaremodell för att studera den patogena rollen av mekanisk stress i Crohns sjukdom
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En TNBS-inducerad gnagaremodell för att studera den patogena rollen av mekanisk stress i Crohns sjukdom

Article DOI: 10.3791/63499-v • 05:08 min • March 1st, 2022
March 1st, 2022 •
*1, *1, *1, 2, 1
1Department of Internal Medicine, the University of Texas Medical Branch, 2Department of Pathology, the University of Texas Medical Branch
* These authors contributed equally

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Det föreliggande protokollet beskriver utvecklingen av en Crohns-liknande kolitmodell hos gnagare. Transmural inflammation leder till stenos vid TNBS-instillationsstället, och mekanisk utvidgning observeras i segmentet proximalt till stenosen. Dessa förändringar gör det möjligt att studera mekanisk stress vid kolit.

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Immunologi och infektion utgåva 181
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