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JoVE Journal
Immunology and Infection

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Studying Inherited Immunity in a Caenorhabditis elegans Model of Microsporidia Infection
 

Studying Inherited Immunity in a Caenorhabditis elegans Model of Microsporidia Infection

Article DOI: 10.3791/63636-v 09:24 min April 6th, 2022
April 6th, 2022

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Summary

The infection of Caenorhabditis elegans by the microsporidian parasite Nematocida parisii enables the worms to produce offspring that are highly resistant to the same pathogen. This is an example of inherited immunity, a poorly understood epigenetic phenomenon. The present protocol describes the study of inherited immunity in a genetically tractable worm model.

Tags

Inherited Immunity Caenorhabditis Elegans Microsporidia Infection Intergenerational Immunity Molecular Mechanisms Nematode Growth Medium Synchronized L1 Worms Escherichia Coli Strain OP50 N.parisii Spores Uninfected Control
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