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Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes
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JoVE Journal Medicine
Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes

Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes

DOI:
10.3791/63820-v

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04:40 min

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July 07, 2023

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, , , , , ,
1Vifor Pharma Group,Vifor Pharma Management Ltd, 2Section of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Western Switzerland (ISPSO),University of Geneva

Chapters

  • 00:04Introduction
  • 00:51Operating the Machine
  • 03:03Results: Size Distribution and Comparison of Analyzable Parameters
  • 03:39Conclusion

Summary

Automatic Translation

Automatic Translation

Dynamic light scattering (DLS) has emerged as a suitable assay for evaluating the particle size and distribution of intravenously administered iron-carbohydrate complexes. However, the protocols lack standardization and need to be modified for each iron-carbohydrate complex analyzed. The present protocol describes the application and special considerations for the analysis of iron sucrose.

Tags

Keywords: Dynamic Light ScatteringDLSParticle SizeIron-carbohydrate ComplexesNanoparticlesPolydispersityIron SucroseSample PreparationMeasurement Procedure

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