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Intravitreal Injections in the Ovine Eye

JoVE Journal
Medicine

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JoVE Journal Medicine

Intravitreal Injections in the Ovine Eye

Intravitreal Injections in the Ovine Eye

DOI:

10.3791/63823-v

•

03:37 min

•

July 05, 2022

•

Samantha J. Murray, Nadia L. Mitchell

¹Faculty of Agriculture and Life Sciences,Lincoln University

Chapters

00:05Introduction
00:52Surgical Procedure
01:30Viral Administration
02:11Results: ERG Response, Retinal Thickness, and GFAP Immunoreactivity in CLN5 Sheep Retina after AAV9•CLN5• Administration
03:05Conclusion

Summary

Automatic Translation

Intravitreal injections were performed in the sheep eye with the aim of delivering viral-mediated gene therapy to the retina.

Tags

Intravitreal Injections Sheep Eye Gene Therapy Retinal Degeneration Neuronal Ceroid Lipofuscinoses Povidone Iodine Electroretinography Retinal Histology GFAP Therapeutic Agents Vitreous Humor

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