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Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model

JoVE Journal
Behavior

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JoVE Journal Behavior

Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model

Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model

DOI:

10.3791/63997-v

•

06:20 min

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September 01, 2023

•

Marena A. Montera, Aleyah E. Goins, Sascha R. A. Alles, Karin N. Westlund

¹Department of Anesthesiology & Critical Care Medicine,University of New Mexico Health Sciences Center

Chapters

00:00Introduction
00:35Induction of Chronic Back Pain Model
01:55Behavioral Assays
05:08Results: Nociceptive‐Related Behavioral Testing and Data Analysis
05:56Conclusion

Summary

Automatic Translation

Methods for simple, rapid induction of a back pain model in mice are provided here using an intraligament injection of urinary plasminogen activator.

Tags

Keywords: Urokinase Plasminogen Activator Mouse Back Pain Non-invasive Chronic Pain Ligament Injection Mechanical Stimulation Hargreaves Test Cold Plate Test

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