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1Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), 2Department of Surgery, Faculty of Medicine,Université de Montréal, 3Division of Cardiac Surgery,Dalhousie University, 4Division of Cardiovascular Surgery, Peter Munk Cardiac Centre,Toronto General Hospital, 5Department of Surgery,University of Toronto
Chapters
- 00:04Introduction
- 00:45Establishing Surgical Access
- 02:16Withdrawal of Life‐Sustaining Therapies
- 02:54Placement of Thoracoabdominal Normothermic Regional Perfusion and Cardiac Evaluation
- 06:31Results: Cardiac Functional Assessment After Normothermic Regional Perfusion
- 07:19Conclusion
The protocol describes a large-animal (porcine) model of donation after circulatory death, followed by thoracoabdominal normothermic regional perfusion that closely simulates the clinical scenario in heart transplantation, and has the potential to facilitate therapeutic studies and strategies.
Tags
Keywords:
Large-animal ModelDonation After Circulatory DeathNormothermic Regional PerfusionCardiac AssessmentTranslational ResearchBoar SwineHeart TransplantationMidline IncisionSternotomyPericardiotomyHeparinAnticoagulationActivated Clotting TimePropofolCirculatory ArrestFunctional Warm Ischemia TimeAortic Cross-clampingMetzenbaum Scissors
