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X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models

Article DOI: 10.3791/64042-v • 12:57 min • December 9th, 2022
December 9th, 2022 •
1,2, 1,3, 1,2, 1,4, 2,5, 2,6, 7, 2, 1,2
1Precision Health Program, Michigan State University, 2Department of Radiology, Michigan State University, 3Department of Pharmacology & Toxicology, Michigan State University, 4College of Osteopathic Medicine, Michigan State University, 5TechInsights Inc., 6IQ Advanced Molecular Imaging Facility, Michigan State University, 7Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University

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Summary
Automatic Translation

A procedure for the delivery of a chemical ablative solution to the rat mammary ductal tree for image-guided preventive treatment of breast cancer is described. Mammary epithelial cells can be targeted with minimal collateral tissue damage through cannulation directly into the nipple opening and intraductal infusion of a 70% ethanol-based ablative solution.

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X-ray Visualization Intraductal Ethanol-based Ablative Treatment Prevention Of Breast Cancer Rat Models In Vivo Imaging Mammary Ductal Tree Nipple Opening Mammary Epithelial Cells Collateral Tissue Damage Ablation Success Ethyl Cellulose Image Verified Breast Cancer Prevention Dosing Animals Carprofen Orally Sucralose Gel Cups
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