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Virale transgene expressie in knaagdierharten en de beoordeling van het risico op hartritmestoornissen
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Virale transgene expressie in knaagdierharten en de beoordeling van het risico op hartritmestoornissen

Article DOI: 10.3791/64073-v • 05:15 min • July 27th, 2022
July 27th, 2022 •
1,2, 1,2, 1,2, 1, 1,2, 1,3, 1,2, 1, 1,2
1University of Ottawa Heart Institute, 2Department of Cellular and Molecular Medicine, University of Ottawa, 3Department of Biochemistry, Microbiology and Immunology, University of Ottawa

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Het huidige protocol beschrijft methoden voor transgene expressie in ratten- en muizenharten door directe intramyocardiale injectie van het virus onder echocardiografiebegeleiding. Methoden voor de beoordeling van de gevoeligheid van harten voor ventriculaire aritmieën door de geprogrammeerde elektrische stimulatie van geïsoleerde, langendorff-doordrenkte harten worden hier ook uitgelegd.

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Biologie Nummer 185
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