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Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
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Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Article DOI: 10.3791/64265-v • 10:30 min • August 4th, 2022
August 4th, 2022 •
1,2, 1,2, 1,2, 1,2, 1,2,3
1Stanford Cardiovascular Institute, Stanford University School of Medicine, 2Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 3Department of Radiology, Stanford University School of Medicine

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Summary
Automatic Translation

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising in vitro model for drug-induced cardiotoxicity screening and disease modeling. Here, we detail a protocol for measuring the contractility and electrophysiology of hiPSC-CMs.

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Microelectrode Array Patch Clamp Recordings Human Induced Pluripotent Stem Cells Cardiomyocytes Cardiac Safety Assessment Drug Development Disease Modeling Drug-induced Cardiotoxicity Screening Precision Medicine Toxicity Prediction Culturing Temperature Controller Microscope Camera Carbon Dioxide Supply Water Jacket 96-well Plate Incubate Cells View Software Camera Frame Rate Video/image Resolution
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