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Laserinducerede aktionspotentialelignende målinger af kardiomyocytter på mikroelektrodearrays for øget forudsigelighed af sikkerhedsfarmakologi
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Laserinducerede aktionspotentialelignende målinger af kardiomyocytter på mikroelektrodearrays for øget forudsigelighed af sikkerhedsfarmakologi

Article DOI: 10.3791/64355-v • 10:41 min • September 13th, 2022
September 13th, 2022 •
1, 1, 1, 1
1NMI Natural and Medical Sciences Institute at the University of Tübingen, Germany,

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Kombinationen af laserporation og mikroelektrodearrays (MEA) tillader handlingspotentialelignende optagelser af dyrkede primære og stamcelleafledte kardiomyocytter. Bølgeformformen giver overlegen indsigt i testforbindelsers virkemåde end standardoptagelser. Det forbinder patch-clamp og MEA-udlæsning for yderligere at optimere cardio-sikkerhedsforskning i fremtiden.

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