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Suzuki Cross-Coupling 및 Alkene Boracarboxylation 반응을 통한 Borylated Ibuprofen 유도체의 합성
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
DOI:

08:56 min

November 30, 2022

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Chapters

  • 00:04Introduction
  • 00:52Synthesis of 4-Isobutylstyrene by Suzuki Cross-Coupling of 1-Bromo-4-Isobutylbenzene and Vinylboronic Acid Pinacol Ester
  • 03:17Benchtop Large-Scale Synthesis of Bora-Ibuprofen
  • 06:30Results: Characterization of 4-Isobutylstyreneand Bora-Ibuprofen Using 1H, 13C,and 11B NMR Spectroscopy
  • 08:15Conclusion

Summary

Automatic Translation

본 프로토콜은 이부프로펜의 독특한 보릴화 유도체를 생성하는 상세한 벤치탑 촉매 방법을 설명합니다.

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