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En perinatal asfyximodell för smågrisar för att studera hjärtskada och hemodynamik efter hjärtstopp, återupplivning och återkomst av spontan cirkulation
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En perinatal asfyximodell för smågrisar för att studera hjärtskada och hemodynamik efter hjärtstopp, återupplivning och återkomst av spontan cirkulation

Article DOI: 10.3791/64788-v • 10:55 min • January 13th, 2023
January 13th, 2023 •
1,2, 2, 3, 3,4, 5, 6,7, 6,7, 8,9, 10,11, 1,2, 2
1Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 2Department of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, 3Department of Pediatric Research, Division of Paediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, 4Department of Pediatrics, Vestfold Hospital Trust, 5Department of Anesthesiology, Oslo University Hospital Rikshospitalet, 6Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 7Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, 8Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, 9Department of Paediatrics and Adolescent Health, University of Botswana, 10Department of Pediatric Research, Oslo University Hospital, University of Oslo, 11Department of Pediatrics, Robert H Lurie Medical Research Center, Northwestern University Chicago

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Denna grismodell involverar kirurgisk instrumentering, kvävning fram till hjärtstillestånd, återupplivning och observation efter återupplivning. Modellen möjliggör multipel provtagning per djur, och genom att använda kontinuerligt invasivt arteriellt blodtryck, EKG och icke-invasiv hjärtminutvolymövervakning ger den kunskap om hemodynamik och hjärtpatofysiologi vid perinatal asfyxi och neonatal hjärt-lungräddning.

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Medicin nummer 191
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