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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
JoVE Journal
Biology
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JoVE Journal Biology
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
DOI:

08:41 min

March 24, 2023

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Chapters

  • 00:04Introduction
  • 01:06Animal Preparation and Imaging Workflow
  • 02:02Evaluation of Hepatic Lipid Deposition/Steatosis
  • 03:21Functional Tissue Uptake/Lipid (Chylomicron) Transfer in the Liver
  • 04:27Architecture and Density of the Hepatic Vascular Network
  • 05:32Hepatic Relative Blood Volume
  • 06:33Results: Average Contrast Values and the Micro‐CT Imaging in Mice with NAFLD and Healthy Controls
  • 07:50Conclusion

Summary

Automatic Translation

Using a diet-induced non-alcoholic fatty liver disease (NAFLD) mouse model, we describe the use of novel in vivo micro-computed tomography imaging techniques as a non-invasive method to assess the progression stages of NAFLD, focusing predominantly on the hepatic vascular network due to its significant involvement in NAFLD-related hepatic dysregulation.

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